DHT Blockers

DHT is strongly linked to hair loss, with research showing that it’s the main hormone responsible for hair loss in men.

Finast

Finasteride

A powerful DHT blocker, clinically proven to help stop hair loss and promote regrowth

How does it work?
Caret

Blocks one form of the 5-alpha reductase enzyme which produces DHT, reducing the hormone’s impact on follicles.

How effective is it?
Caret

Reduces DHT levels by 70%. Studies show that Finasteride reduced hair loss or promoted regrowth in 8 out of 10 men.

What are the advantages?
Caret

The once daily tablet is the most effective licensed treatment for hair loss in the UK.

Dutast

Dutasteride

A potent DHT blocker that blocks up to 20% more DHT than Finasteride.

How does it work?
Caret

Blocks two forms of the 5-alpha reductase enzyme which produces DHT, reducing the hormone’s impact on follicles

How effective is it?
Caret

Reduces DHT levels by 90%. Studies show that Dutasteride is more effective at reducing DHT levels than any other treatment on the market

What are the advantages?
Caret

A highly effective, convenient once daily tablet.

Earim
Dr. Earim Chaudry, Medical Director
“Dutasteride is proven to be up to 20% more effective at blocking DHT than Finasteride”

Join more than 100,000 customers gaining their confidence back

Trustpilot stars
TrustScore 4.3/5
8,471 reviews
Caret
Caret
Day 1
Luke
Month 5
Luke

I couldn’t be happier with the results!

“Manual is the most straightforward, easy and reassuring company when it comes to Finasteride and Minoxidil, I’ve had help every step of the way if I’ve required it and I couldn’t be happier with the results!”

Day 1
Leo
Month 5
Leo

Thicker hair

“I though, if 9 out of 10 men can have improved hair, then I’m sure I could”

Day 1
Joe
Month 5
Joe

Really helped with the thickness and texture

“I take the oral tablet once a day, and it’s really helped with the thickness and texture of my hair”

Day 1
Michael
Month 5
Michael

Great experience

“So far, my experience has been great, no side effects and my hair looks and feels thicker and I feel much more confident and happier.”

Day 1
Matt
Month 3
Matt

Feeling myself again!

“My hair really knocked my confidence but this treatment has me feeling myself again - full of confidence and life and worked in only 3 months use!”

Day 1
Richard
Month 6
Richard

Easy to use

“Manual was easy to use and I definitely saw a difference.”

The science behind how DHT Blockers work

Why we lose hair
Why we lose hair

DHT (a male hormone) shrinks your hair follicles causing hair thinning, and eventually baldness.

Finasteride
Finasteride

Finasteride prevents hair loss by blocking  5-alpha reductase enzyme Type I, reducing DHT levels by 70%

Dutasteride
Dutasteride

Dutasteride prevents hair loss by blocking both Type I and Type II 5-alpha-reductase enzymes, reducing DHT levels by 90%

Why we lose hair

DHT (a male hormone) shrinks your hair follicles causing hair thinning, and eventually baldness.

Finasteride

Finasteride prevents hair loss by blocking  5-alpha reductase enzyme Type I, reducing DHT levels by 70%

Dutasteride

Dutasteride prevents hair loss by blocking both Type I and Type II 5-alpha-reductase enzymes, reducing DHT levels by 90%

What’s the difference between Finasteride and Dutasteride

Dutasteride
Finasteride
The science
Blocks two 5-alpha reductase enzymes
Blocks one 5-alpha reductase enzyme
Action
Reduces DHT by up to 90% 
Reduces DHT by up to 70% 
Dosage
Taken once daily
Taken once daily
Results
In 3-6 months
In 3-6 months
Safety
Generally considered safe for long-term use
Generally considered safe for long-term use
DHT blocker

DHT Blockers compared

Read our full Guide to Dutasteride & Finasteride

Real men. Real results

Trustpilot stars
TrustScore 4.3/5
8,471 reviews
Aftab, 39
Thicker hair
Regrowth
Callum, 24
Thicker hair
Less shedding
Tom, 35
Regrowth
Less shedding
Ace, 32
Scalp coverage
Regrowth
Close

How it works

1

Take our assessment

Answer a few questions to help us understand your symptoms.

2

Receive your treatments

Next day delivery, discretely packaged

3

Get ongoing support

Speak to your clinician at any point

Phone
Everything happens on your phone
Delivery
Free next day delivery (medication)
Pause
Cancel or pause anytime subscription

As seen in

Metro logoThe guardianThe telegraphIndependentHuffpostChannel 5 logoTechcrunch logoitv logo

Meet our medical team

Enabling the mission of revolutionising how men approach health, they are at the core of the men’s wellness platform.

Caret
Caret
Earim

Earim Chaudry, MD

Medical Director
Eve

Eve Agwuncha

Pharmacist, Ind. Prescriber
Bentley

Bentley Ifediora-Ezike

Pharmacist, Ind. Prescriber

Read me, I’m important

What is male pattern baldness?
Caret

Male pattern baldness (MPB), androgenetic alopecia, male pattern hair loss – call it what you will. If you have a receding hairline or balding crown, the single most common cause is your hormones. Specifically, that’s dihydrotestosterone (DHT), a hormone your body converts from testosterone. DHT binds to your hair follicles and causes them to shrink, weaken, and stop producing hair. That’s MPB in a nutshell.

How do DHT blockers work?
Caret

DHT blockers work by targeting the production of DHT. Remember that DHT is made from the conversion of testosterone, which is done using an enzyme called 5-alpha-Reductase. DHT blockers bind to this enzyme, preventing it from producing DHT.
This reduces the circulating level of DHT, explaining the role of DHT blockers in hair loss prevention. 
Many treatments for male pattern baldness only seek to manage the symptoms of the condition. But by using an effective DHT blocker you can tackle the cause of MPB directly and fight hair loss head-on.

Does it really reverse hair loss?
Caret

There are no better 5-alpha reductase inhibitors on the market for hair loss.

Finasteride causes DHT levels to drop by 60%. Meanwhile, three 5-year Finasteride studies showed 9/10 participants saw their hair loss stop – and more than 3/4 experienced hair regrowth. So, yes, Finasteride does really reverse hair loss. It is an FDA-approved treatment for MPB, and it is used by thousands of men in the UK.

How long will it take to see results?
Caret

It typically takes 3-6 months before you see any changes, and at least 12 months before you notice significant hair growth. Finasteride works with the natural cycle of shedding and growth – and, unfortunately, these things just take time. Stay committed and take your daily dose – and you’ll see noticeably better hair within a year. When you use Finasteride, persistence and patience are key.

What are the side effects?
Caret

98.6% of patients during clinical trials did not experience significant adverse effects. Although side effects are rare, it may include a rash, tenderness around the nipple and decreased libido.

Learn more about hair loss

Caret
Caret